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Image Search Results
Journal: World Journal of Gastroenterology
Article Title: Abdominal paracentesis drainage ameliorates myocardial injury in severe experimental pancreatitis rats through suppressing oxidative stress
doi: 10.3748/wjg.v26.i1.35
Figure Lengend Snippet: Effects of abdominal paracentesis drainage on pancreatic histopathology and proinflammatory cytokines. A: Representative micrographs of hematoxylin-eosin stained sections of rat pancreatic tissue from different groups. Images were taken under 100 × and 200 × magnification. The arrow indicates necrotic pancreatic tissue; B: Histology severity score of pancreas; C: Amylase; D: Interleukine-1 beta; E: Tumor necrosis factor alpha; F: Endotoxin; G: High mobility group box 1. Data indicate the mean ± standard deviation obtained from six animals in each group (C-G). a P < 0.05 vs sham group; c P < 0.05 vs severe acute pancreatitis group. IL-1β: Interleukine-1 beta; TNF-α: Tumor necrosis factor alpha; HMGB1: High mobility group box 1; PAAF: Pancreatitis associated ascitic fluids; SAP: Severe acute pancreatitis; APD: Abdominal paracentesis drainage.
Article Snippet: Nonimmune chicken IgY (
Techniques: Histopathology, Staining, Standard Deviation
Journal: World Journal of Gastroenterology
Article Title: Abdominal paracentesis drainage ameliorates myocardial injury in severe experimental pancreatitis rats through suppressing oxidative stress
doi: 10.3748/wjg.v26.i1.35
Figure Lengend Snippet: Effects of pancreatitis associated ascitic fluids intraperitoneal injection with or without anti-high mobility group box 1 neutralizing antibody on cardiac NOX expression in cerulein rats. A: High mobility group box 1 in the serum; B: Nicotinamide adenine dinucleotide phosphate oxidase-2 ( NOX2 ) and NOX4 mRNA measurement by real-time polymerase chain reaction; C: Immunoblot of NOX2 and NOX4 protein expression from heart samples; D: Densitometry analysis of NOX2 and NOX4. Data indicate the mean ± standard deviation obtained from six animals in each group (A-B). Data are representative of at least three independent experiments (C-D). a P < 0.05 vs controls group; c P < 0.05 vs pancreatitis-associated ascitic fluid injection group. HMGB1: High mobility group box 1; NOX2: Nicotinamide adenine dinucleotide phosphate oxidase-2; NOX4: Nicotinamide adenine dinucleotide phosphate oxidase-4; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; SAP: Severe acute pancreatitis; APD: Abdominal paracentesis drainage.
Article Snippet: Nonimmune chicken IgY (
Techniques: Injection, Expressing, Real-time Polymerase Chain Reaction, Western Blot, Standard Deviation
Journal: World Journal of Gastroenterology
Article Title: Abdominal paracentesis drainage ameliorates myocardial injury in severe experimental pancreatitis rats through suppressing oxidative stress
doi: 10.3748/wjg.v26.i1.35
Figure Lengend Snippet: Possible mechanisms responsible for the protective effects of abdominal paracentesis drainage on severe acute pancreatitis associated cardiac injury. During pancreatitis, high levels of high mobility group box 1 (HMGB1) in the bloodstream can trigger a lethal inflammatory process and participate in the development of remote organ injury. Following abdominal paracentesis drainage treatment, the levels of high mobility group box 1 in the circulation decrease significantly, resulting in inhibition of expression and activity of cardiac nicotinamide adenine dinucleotide phosphate oxidase, thus reactive oxygen species production markedly decreases. These events downregulate expression of caspase-associated proteins and alleviate apoptosis, thereby yielding beneficial effects. HMGB1: High mobility group box 1; APD: Abdominal paracentesis drainage; NOX: Nicotinamide adenine dinucleotide phosphate oxidase; ROS: Reactive oxygen species.
Article Snippet: Nonimmune chicken IgY (
Techniques: Inhibition, Expressing, Activity Assay
Journal: Frontiers in Medicine
Article Title: Inflammasome Activation in Pulmonary Arterial Hypertension
doi: 10.3389/fmed.2021.826557
Figure Lengend Snippet: Pre-clinical and clinical evidence for inflammasomes in PAH.
Article Snippet: HMGB1 ,
Techniques: Expressing, Mouse Assay